A VALIDATED RP- HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND NAPROXEN IN TABLET FORMULATION
AbstractThe study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 µm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent flow rate of 1.0 ml/min, and UV detection wavelength 263 nm. The developed method was statistically validated for linearity, precision, robustness, ruggedness and specificity. The method was linear over the range of 5-80 µg/ml for paracetamol and 3-48µg/ml for naproxen.
Article Information
27
3742-3745
326KB
1084
English
Ijpsr
Karuna B. Singh*, Shekhar B. Waikar and Suhas P. Padmane
Gurunanak College of Pharmacy, Nari, Kamptee road, Nagpur 440026, Maharashtra, India
me.karuna_singh@rediffmail.com
11 July, 2012
18 September, 2012
29 September, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3742-45
01 October, 2012
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