FORMULATION, TASTE MASKING AND EVALUATION OF ALMOTRIPTAN ORAL DISINTEGRATING TABLETS
AbstractThe aim of the present study is to formulate and evaluate taste masked Almotriptan orally disintegrating tablet by using different taste masking agents and different superdisintegrants in different ratios, Almotriptan is a triptan class anti-migraine drug with rapid action, highest bioavailability and low side effects compared to other triptan class of drugs used in the treatment of migraine, Thus formulating Almotriptan as an orally disintegrating tablet is extremely advantageous. However due to its bitter taste formulating Almotriptan into an orally disintegrating tablet is a challenge. Two taste masking agents namely Eudragit EPO and Precirol A To5 are used to taste mask the drug. The oral disintegrating tablets of Almotriptan were prepared using different superdisintegrants and the effect of different superdisintegrants at different concentration on in-vitro release was studied. Almotriptan release from ODT was directly proportional to the concentration of the superdisintegrant used. The optimized formulation was found to release the drug in minimum time and is found to be stable.
Article Information
58
3940-3946
886KB
1524
English
Ijpsr
Akhila Alladi* and N. Damodharan
Department of Pharmaceutics, SRM College of Pharmacy, Chennai- 603 203, Tamil Nadu, India
akhila_alladi@yahoo.com
23 June, 2012
22 September, 2012
26 September, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3940-46
01 October, 2012
Download