NON-PROLIFERATIVE ACTIVITY OF SAPONINS ISOLATED FROM THE LEAVES OF GYMNEMA SYLVESTRE AND ECLIPTA PROSTRATA ON HEPG2 CELLS- IN VITRO STUDY
AbstractThe non-proliferative activity of isolated saponins, gymnemagenol (C30H50O4) from Gymnema sylvestre and dasyscyphin C (C28H40O8) from Eclipta prostrata leaves were tested under on HepG2 cells under in vitro conditions. Both gymnemagenol and dasyscyphin C exhibited non-proliferative activity on HepG2 cells at 24 h with the IC50 value of 18.5 and 23.5μg/ml respectively. 5-Fluorouracil (5FU) a positive control showed the IC50 value of 1.34μg/ml. The isolated saponins were not toxic to Vero cells. From this study, it can be concluded that the saponins, gymnemagenol and dasyscyphin C have significant non-proliferative activity on HeLa cells under in vitro conditions.
Article Information
4
38-42
523 kB
1147
English
IJPSR
Venkatesan Gopiesh Khanna and Krishnan Kannabiran*
School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
kkb@vit.ac.in
15 March, 2010
14 June, 2010
02 July, 2010
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8).38-42
01 August, 2010
Download