STUDY THE EFFECT OF PROCESS VARIABLES IN FLUID BED GRANULATION ON THE PHYSICO-CHEMICAL PROPERTIES OF GRANULES
AbstractThe purpose of this research was to improve the granulation efficiency and the final granule characteristics for the any kind of the material that is to be granulated via FBG process. The fluid bed granulation process is an influenced by various processing parameters like atomization pressure, binder addition rate, in let temperature etc. These process variables largely affect the granulation efficiency and the final granule characteristics. The effect of starting materials on granule properties was previously studied. The aqueous solution of 5% PVP K-30 was used as a binder and sprayed on lactose monohydrate bed. A full factorial design was applied to optimized the granulation process variables like inlet air temperature, spray rate and batch size and other granule properties, namely the Carr’s index, Hausner index, the angle of repose and the moisture content, were evaluated at the optimal operation conditions. Granules prepared by this technology have good flow property, good compressibility; and good flow ability with a proper adjustment of process variables. So FBG technique has its own importance for the granulation purpose in the pharmaceutical industry and technology.
Article Information
23
370-377
475
1635
English
Ijpsr
Virendra K. Singh*, Arvind K. Singh, Mukesh K. Dubey and Satyawan Singh
Department of Pharmacy, Rameshwaram Institute of Technology & Management, Lucknow, Uttar Pradesh, India
07 September, 2010
02 November, 2010
10, January 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(2).370-77
01 February, 2011
Download