PREPARATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF VERAPAMIL
AbstractMucoadhesive microcapsules of verapamil, a peripheral vasodilator, used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, have been prepared from sodium alginate, hydroxypropylmethyl cellulose- K4M & E5LV, Carbopol 934P using 10% w/v calcium chloride solution by ionic gelation method. Drug : polymer ratio was 1:1 in all formulations and polymer mixtures employed were 1:1, 2:1, 3:1, 4:1 of sodium alginate: polymer (hydroxypropyl methyl cellulose- K4M & E5LV, carbopol 934P). Calcium chloride was used for ionic gelatin and cross linking of sodium alginate molecules. Microcapsules were spherical in shape and of sizes between 580 microns to 831 microns. Carbopol 934P was found most effective in controlling drug release from microcapsules followed by hydroxypropyl methyl cellulose- K4M. Drug releases from the best formulations of carbopol 934P and hydroxypropyl methyl cellulose-K4M follow anomalous transport.
Article Information
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664-670
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EnglishPREPARATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF VERAPAMIL Niranjan Kumar Manna* and Nikesh Kumar Department of Pharmaceutics, College of Pharmaceutical Sciences, Mahuda, Berhampur, Ganjam, Orissa, India
Ijpsr
Niranjan Kumar Manna* and Nikesh Kumar
Department of Pharmaceutics, College of Pharmaceutical Sciences, Mahuda, Berhampur, Ganjam, Orissa, India
18 October, 2010
21 November, 2011
14 January, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(3).664-70
01 March, 2011
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