ASSESSMENT OF ANTIDIABETIC POTENTIAL OF CAESALPINIA DIGYNA ROTTLER ROOT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS

This study was undertaken to investigate the antidiabetic activity effect of repeated oral administration of the methanolic extract of Caesalpinia digyna (Family: Leguminosae) in normal and streptozotocin induced diabetic rats, respectively. The effect of repeated oral administration of methanolic extract on serum lipid profile in diabetic rats was also examined. The doses, viz. 250 and 500mg/kg bw of methanolic extract of Caesalpinia digyna (CD) were evaluated and the dose of 500 mg /kg was found to be the most effective dose. The same dose of 500 mg/kg produce significant fall in blood glucose level after 1h during glucose tolerance test. The dose has almost similar effect as similar to that of glibenclamide (0.4 mg/kg bw). The diabetic rats treated daily with 500mg/kg bw for 15 days produced a significant reduction in the fasting blood glucose level and increase in body weight of diabetic rats was additional corroborating factors for its antidiabetic potential. Total cholesterol (TC), low density lipoprotein (LDL) and triglycerides (TG) levels were significantly (p<0.01) decreased when compared to control diabetic rats. Were as, cardioprotective, high density lipoprotein (HDL) was significantly (p<0.01) increased when compared to control diabetic rats. These results clearly indicate that methanolic extract of CD has high antidiabetic potential along with significant hypolipidemic effects.

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