COMPATIBILITY AND STABILITY STUDIES OF AMPICILLIN TRIHYDRATE AND PIPERINE MIXTURE
AbstractAmpicillin is used to treat variety of Bacterial infections in Humans. Piperine, an alkaloid from Piper species is reported to enhance oral bioavailability of co-administered drugs. The present study was aimed to include to Piperine (bioenhancer) as a formulation additive in oral formulations of Ampicillin Trihydrate. So, a Physical mixture of Ampicillin Trihydrate and Piperine (1:1) was tested for their compatibility by DSC, TLC and FT-IR techniques. Stability of the mixture was assessed by the use of ICH guidelines. The above studies have proved that Piperine can be used as a formulation additive (bioenhancer), in oral formulations of Ampicillin Trihydrate.
Article Information
10
1176-1181
704
1366
English
Ijpsr
K. Janakiraman* and R. Manavalan
Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India
27 December, 2011
10 February, 2011
24 April, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(5).1176-81
01 May, 2011
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