SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF N-{4-[(6-CHLORO-4-OXO-4H-CHROMEN-3-YLMETHYLENE) IMINO] PHENYL}-2-(SUBSTITUTED PHENOXY ACETAMIDE) DERIVATIVES
AbstractSome N-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene) imino] phenyl}-2-(substituted phenoxy) acetamide derivatives (3) were synthesized by reacting N-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene) imino] phenyl}-2-chloroacetamide (2) with some substituted phenol in dry acetone in the presence of K2CO3 and catalytic amount of KI. The chemical structures of the compounds were elucidated by IR, 1H-NMR and elemental analysis. Their antibacterial activity against gram positive bacterial strains (S. aureus and B. subtilis) and gram negative bacterial strains (E. coli and P. aeruginosa) were investigated by disc diffusion method. The antifungal activity of these compounds was also tested against A. niger and A. flavipes. The results showed that some of the compounds have strong antimicrobial activity.
Article Information
23
1495-1501
578KB
908
English
Ijpsr
S. K. Deivedi*, V. K. Singh and D. C. P. Singh
Lecturer, College of Pharmacy, IFTM, Lodhipur Rajput, Delhi Road, Moradabad- 244001, Uttar Pradesh, India
11 February, 2011
21 April, 2011
26 May, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(6).1495-01
01 June, 2011
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