ANTIHYPERLIPIDEMIC AND HEPATOPROTECTIVE EFFECTS OF DIFFERENT FRACTIONS OF BRASSICA OLERACEA IN ALLOXAN INDUCED DIABETIC RATS
AbstractThe study was undertaken to investigate the hypolipidemic and hepatoprotective effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Brassica oleracea. The different fractions of extract were administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduce blood lipid level (Total cholesterol and Triglycerides) significantly (p<0.05). The plant fractions also exhibited correction of altered biochemical parameters viz., SGOT and SGPT levels in diabetic rats. The effect of plant fractions were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpenes, alkaloids and flavonoids etc. were present in the plant which has hypolipidemic and hepatoprotective properties. Thus, this study indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the ethanolic extract of Brassica oleracea have favorable effect in hypolipidemic and hepatoprotective activities
Article Information
9
1662-1668
653
1275
English
Ijpsr
M. Asadujjaman , M. Sarowar Hossain , M.T.I. Morshed , M. Azizur Rahman , A.S.M Anisuzzaman , Maruf Ahmed and Anwarul Islam*
Ph. D, Associate Professor, Department of Pharmacy, Bangladesh University, 15/1, Iqbal Road, Mohammadpur, Dhaka-1207, Bangladesh
09 March, 2011
07 May, 2011
16 June, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(7).1662-68
01 July, 2011
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