DULOXETINE HYDROCHLORIDE DELAYED RELEASE PELLETS PREPARED BY SUSPENSION LAYER METHOD
AbstractThe aim of present study is to develop a delayed release pellets dosage form of duloxetine hydrochloride with a suitable polymer by using suspension layered method. Drug loaded nuclei was prepared using suspension layered technique in a Fluidized Bed Processor, the nuclei was coated with an acid resistant acrylic polymer (Eudragit L30-D55) and compared acid resistant properties with HPMC phthalate. The entire coating process performed in a Fluidized Bed Processor to different thickness. The in vitro dissolution studies were conducted in 0.1N HCl for 2 hours followed by phosphate buffer (pH 6.8) for 1 hour with USP dissolution tester (type II). The results generated in this study showed that proper selection of polymer material based on their physicochemical properties as well as polymer load is important in designing delayed release pellets dosage form with best fit of dissolution profile
Article Information
43
2741-2745
742
1794
English
Ijpsr
Sk. Zakir Hussain*, S. Bhama, R. Senthil Selvi and L. Srujan
JKK Nataraja College of Pharmacy, Komarapalayam, Namakkal (dt), Tamil Nadu, India
06 May, 2011
24 June, 2011
29 September, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(10).2741-45
01 October, 2011
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