SYNTHESIS AND ANTIDIABETIC EVALUATION OF SOME THIAZOLIDINE-2, 4-DIONE DERIVATIVES
AbstractCondensation of thiaourea with chloro acetic acid gave Thiazolidinedione which react with aromatic aldehyde and produce 5- benzylidine, 2, 4 Thiazolidinedione.To this different secondary amine was reacted and final derivatives was obtained. The structures of these compounds were established by means of IR, 1 H-NMR.All the compounds were evaluated for antidiabetic activities. Most of the compounds have shown significant antidiabetic activity when compared with the standard drug.
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41-50
366 KB
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English
IJPSR
ASHUTOSH MISHRA, GAUTAM V.*, GHANSHYAM, BANDANA SINGH, SWEEMIT J., SAROJ KUMAR
A.N.D College of Pharmacy*, Bhabhnan, Gonda, (U.P.), India
gautam.vrm@gmail.com
4 December, 2009
23 January, 2010
27 January, 2010
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(2).4150
01 February, 2010
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