FORMULATION AND EVALUATION OF MATRIX MICROSPHERES FOR SIMULTANEOUS DELIVERY OF CANDESARTAN CILEXETIL AND CAPTOPRIL FOR TREATMENT OF NEPHRITIC SYNDROME
AbstractThe objective of the present study was to prepare and evaluate matrix microspheres system for simultaneous and sustained release of candesartan cilexetil and captopril for the management of nephritic syndrome, Ethyl cellulose was used as a retardant polymer and IR study showed better compatibility of it with both the drugs, the matrix microspheres were prepared by emulsion solvent evaporation method and the prepared microspheres were characterized for morphology, drug loading and micromeretical properties. The drug release was performed in pH-6.8. The prepared microspheres were spherical in shape and free flowing in nature, the drug loading capacity ranges from 62-86%, the matrix microspheres show extended release up to 6-8 h, thus, the matrix microspheres have a potential for the prolongation and simultaneous release of candesartan cilexetil and captopril for mitigation of nephritic syndrome.
Download