ADAPTIVE REACTIONS INVESTIGATION UNDER EXPERIMENTAL HYPOXIA CONDITIONS WITH THE PRIOR TREATMENT OF THE 4-THIAZOLIDINONE DERIVATIVE
AbstractThe effects of 4-thiazolidinone-derivative – Les-589 as perspective anti-hypoxic agent under the experimental hypoxic hypoxia actions were studied. The values of peripheral blood and hematological indexes as well as parameters of cellular oxidative metabolism (level of lipoperoxidation products, activity superoxide dismutase and catalase, levels and ratio of lactic and pyruvic acids in the blood and liver tissue) of the experimental animals were investigated. The presented data confirm the anti-hypoxic properties of the Les-589 under study conditions and are the strong argument for further Les-589 study as perspective antihypoxant with preventative effect.
Article Information
9
361-367
470KB
1045
English
IJPSR
Оlha І. Antoniv , Svitlana М. Kovalchuk , Оxana І. Terletska, Danylo V. Kaminskyy , Roman B. Lesyk , Оleh R. Pinyazhko*
Department of Pharmacology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
olehpinyazhko@gmail.com
27 September, 2013
29 October, 2013
16 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).361-67
01 February, 2014
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