ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF THE DIFFERENT FRACTIONS OF METHANOLIC EXTRACTS OF ENTADA PHASEOLOIDES (L.) MERR. IN ALLOXAN INDUCED DIABETIC MICE

The antidiabetic effects of Ethyl acetate (Et Ac), Petroleum-ether (Pet ether), and Chloroform fractions from methanolic extract of the seeds of Entada phaseoloides were investigated in alloxan induced diabetic mice (AIDM). The effect of these fractions (200 mg/kg body weight i.p) was observed on fasting blood glucose (FBG) level and active fraction was further investigated for its dose dependent activity (250 and 350 mg/kg b. w.) on fasting blood glucose level and also on total cholesterol (TC), triglyceride (TG), serum glutamate oxaloacetate transaminases (SGOT) and serum glutamate pyruvate transaminases (SGPT) level in AIDM and found significant effects. The most significant reduction of FBG level of around 72.02% was observed for Et-Ac fraction in AIDM. A significant reduction (*p< 0.05) in serum TC and TG level of 53.00% and 57.25% respectively was also found for Et-Ac fraction of E. phaseoloides. The hypoglycemic and hypolipidemic activities were comparable to metformin HCl (150 mg/kg). In diabetic mice, SGOT and SGPT levels were significantly elevated that were further reduced after intraperitoneal administration of this fraction. These results indicate that Et-Ac fraction of E. phaseoloides have favorable effects in bringing down the severity of diabetes together with hepatoprotectivity.