NEUROPATHIC PAIN SYMPTOMS OF POST HERPETIC NEURALGIA PATIENTS WITH CYP2D6 POLYMORPHISM UNDERGOING TRAMADOL TREATMENT
AbstractMain aim of this study was to find out relation of CYP2D6 polymorphism with tramadol action in post herpetic neuralgia (PHN) patients. This non- responders versus responders study mainly includes 246 patients (age group 20-80 years) of PHN, assigned into two groups depending upon their response to tramadol treatment at the end of 2nd week of drug therapy. On the basis of CYP2D6 polymorphism, an allodynia and pins and needles significant interactions were found with CYP2D6*2 allele between time, group and metabolizers while with*4 and *10 alleles no interaction observed. Finally, results not showing role of CYP2D6 polymorphism in the development of neuropathic symptoms in PHN patients
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1489-01
777KB
1080
English
Ijpsr
Namita Vilas Nasare *, Basu Dev Banerjee, Pravin Suryakantrao Deshmukh ,, Pramod Kumari Mediratta , Rafat S Ahmed , Ashok Kumar Saxena and Sambit Nath Bhattacharya
Department of Pharmacology , Environmental Biochemistry and Molecular Biology Laboratory, University College of Medical Sciences & G.T.B. Hospital, Delhi, India
ndharmul@gmail.com
30 August, 2014
13 October, 2014
25 February, 2015
10.13040/IJPSR.0975-8232.6(4).1489-01
01 April, 2015
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