SYNTHESIS OF NOVEL 1, 5-DIHYDROBENZOTHIAZEPINE DERIVATIVES BY CONVENTIONAL AND MICROWAVE IRRADIATION METHODS AND THEIR PHARMACOLOGICAL ACTIVITIES
Abstract1, 5-Dihydrobenzothiazepines are synthesized by conventional and microwave assisted synthesis methods. By microwave assisted synthesis, a considerable increase in the reaction rate has been observed and that too, with better yields. The compounds have been screened for antimicrobial and cytotoxic activity. 1, 5-Dihydrobenzothiazepines are prepared by the reaction of 1, 3-diarylprop-2-enones with o-aminothiophenol. All the products were tested for purity by tlc and characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectral studies.
Article Information
22
453-462
485KB
1294
English
IJPSR
Venkata Rao Vutla*, Rajendra Prasad Yejella and Ramarao Nadendla
Associate Professor, Department of Pharmaceutical Chemistry, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India
vvrao_pharma@yahoo.co.in
11 September, 2013
17 October, 2013
09 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).453-62
01 February, 2014
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