TOXICOLOGICAL EFFECT OF MALLASINDURA (MSL) ON LIVER FUNCTION PARAMETERS OF RAT PLASMA AFTER CHRONIC ADMINISTRATION

Mallasindura (MSL), a widely used ayurvedic preparation is used for the treatment of bronchial asthma. It contains rasa –mercury, Rasakarpura -mercurial compound, Bali –purified and processed sulphur and Malla-purified arsenic oxide with herbal juices.  The liver function parameters of rat plasma were studied after chronic administration of MSL. The animals used to conduct this experiment were albino rats (Rattusnovergicus: Sprague-Dawley strains) and the drug was administered per oral route. The administered dose of the drug was 100mg/kg body weight, once daily up to 90 days for the whole study. There were forty rats for four randomized groups, equally of both sexes. Among them one male and one female group were used as test. In case of male rats, there was increase in total protein and albumin content, which was statistically highly significant with a p value of 0.001. Along with this, a statistically highly significant declining trend was followed for bilirubin, sGPT, sGOT activities (p values are 0.001 and 0.009 respectively). In case of female rats, a statistically highly significant increase was observed for both total protein and albumin with a p value of 0.001. Changes in billlirubin, sGPT and sGOT activities were also reduced and was statistically highly significant (p =0.001). The change observed for ALP content of plasma was statistically insignificant for both of male and female rats