A FACILE SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME MACROCYCLIC COPPER COMPLEXES

Biologically potent compounds are one of the most important classes of materials for the upcoming generations. Increasing number of microbial infectious diseases and resistant pathogens create a demand and urgency to develop novel, potent, safe and improved variety of antimicrobial agents. This initiates a task for current chemistry to synthesize compounds that show promising activity as therapeutic agents with lower toxicity. Therefore, a substantial research is needed for their discovery and improvement. Transition metal complexes share an important place in this regards. Further, it is evidenced that complexation of above metal ions with nitrogen and sulphur donor ligands increases the efficiency of biocidal activity. For the same, metallic soaps of copper (derived from common fatty acids) were complexed with substituted 2-amino benzothiazole derivatives. Complexes were characterized by elemental analysis IR, NMR and ESR spectral data. Their purity was checked by Thin Layer Chromatography. Their antimicrobial efficacy / biological activity was examined against selective bacteria such as Pseudomonas aeruginosa (Gram negative), Lactobacillus aciedophillus (Gram positive), antifungal activity against Fusarium semitectum and Trichophyton ruburum by Kirby-Bauer and Stokes’ method. The transition metal complexes showed good antibacterial and antifungal activity than the free ligands because chelation increases the anti-microbial potency.