DETERMINATION OF LAFUTIDINE THROUGH OXIDATIVE COUPLING REACTION IN BULK SAMPLE AND DOSAGE FORMS- A NEW APPROACH
AbstractA simple, sensitive, highly accurate method has been developed for the determination of Lafutidine in bulk sample and dosage forms. This method is based on the oxidative coupling reaction of drug with 3-methyl-2-benzothialinone hydrazine hydrochloride (MBTH) reagent in the presence of ferric chloride to form green colored chromogen exhibiting maximum absorption at 630 nm. Beer’s law was obeyed and quantitative results were obtained in the range of 1-18µg/mL. The results of the analysis for the methods have been validated statistically.
Article Information
46
2626-30
419
1680
English
Ijpsr
M. Srinivasa Reddy and B. Hari Babu *
Department of Chemistry, Acharya Nagarjuna University, Guntur, A.P., India
dr.b.haribabu@gmail.com
01 November, 2014
19 December, 2014
15 February, 2015
10.13040/IJPSR.0975-8232.6(6).2626-30
01 June, 2015
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