DESIGN AND EVALUATION OF DILTIAZEM HYDROCHLORIDE LOADED BUCCAL PATCH
AbstractThe purpose of this study was to develop and optimise the formulation of mucoadhesive patches of Diltiazem hydrochloride using chitosan as base matrix. The patches were prepared by solvent casting method. PVP (K30) and propylene glycol were introduced into the patches formulae to improve the filming properties. The patches were found to be smooth in appearance, uniform in thickness, weight, and drug content and also showed good mucoadhesive strength and folding endurance and moderate swelling properties. The permeation study of the patches indicated a drug release of 80% in 10 hrs. The data analysis of the release profile using Peppas model indicated a non Fickian type of release profile. It can be concluded that buccal patch of Diltiazem hydrochloride can be an alternate for improving bioavailability with a control release profile.
Article Information
33
556-562
541KB
1072
English
IJPSR
Preethi Sudheer* and A. Ramakrishna Shabaraya
Krupanidhi College of Pharmacy, Bangalore, Karnataka, India
preetisudheer@gmail.com
24 September, 2013
25 October, 2013
14 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).556-62
01 February, 2014
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