PULSATILE DRUG DELIVERY SYSTEM – A REVIEW
AbstractPulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus drug can be delivered at right time, in right amount and at right site of action by use of such approach. The potential benefits of chronotherapeutics have been investigated and established for number of diseases like asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcer, hypercholesterolemia etc. Various capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membranes are available in market. These systems are beneficial for diseases showing chronopharmacological behavior where night time dosing is required or for the drugs having high first pass effect or having site specific absorption in GIT, or for drugs with high risk of toxicity or tolerance. These systems also improve patient compliance by decreasing dosing frequency
Article Information
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3676-88
682
3034
English
Ijpsr
Vidhi R. Patel * and Vipulbhai P. Patel
Department of Pharmaceutical Technology, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India
vidhi21989@gmail.com
17 February, 2015
04 April, 2015
14 May, 2015
10.13040/IJPSR.0975-8232.6(9).3676-88
01 September, 2015
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