NOVEL BULK FORMING LAXATIVE FROM WATERMELON RIND

A laxative formulations are widely used for treatment of constipation. They are classified based on their mechanism of action such as bulk forming, stool softener, osmotic, stimulant and mechanical. Bulk forming laxative is most commonly used laxative which works   by absorbing water and swelling in small and large intestine to form soft and bulky stool. Presently available bulk forming laxative gives adverse effects such as stomach pain, discomfort and vomiting due to sudden swelling in stomach. Therefore present work was conducted for study of novel bulk forming laxative and minimization of associated adverse effects. Bulk laxative formulation was prepared from watermelon rind, isabgol husk and pectin. Watermelon rind powder (WRP) was prepared and analyzed for proximate composition, carbohydrate content, functional properties and performed for topography by scanning electron microscope. Further, effect of pH on swelling index of WRP was studied at pH 1.3, pH 4.5, pH 6 and pH 7.4. Bulk laxative formulations were developed by varying the concentration of WRP, isabgol and pectin. Developed formulations were evaluated for bulk density, tapped density, compressibility index, flowability and swelling index. High swelling index formulations were compared with market sample for pH dependant swelling at pH 1.3, pH 4.5, pH 6 and pH 7.4. From this study WRP was found as novel potential bulk forming laxative in combination with isabgol and pectin. Developed formulation has site specific action due to pH dependant swelling which might decrease the intensity of adverse effects.