AMELIORATION OF DIABETES BY SWIETENIA MAHAGONI IN STREPTOZOTOCIN INDUCED DIABETIC RATS
AbstractSweitenia mahagoni is a natural medicine used to treat various human ailments including diabetes. The present study is a comprehensive approach which targets more than one locus in the diabetic model to enumerate the anti-diabetic potential of Swietenia mahagoni as claimed by folklore. Oral administration of the aqueous extract of the leaf decreased the fasting blood glucose level (155.2±6.7) from its initial value (309.8±10.5) in diabetic rats. There was improvement in the content of innate antioxidant components viz., glutathione (0.570±0.01) when compared to positive control group (0.28±0.02). The activity liver health marker enzymes in the serum were also decreased in the treated group compared to untreated diabetic group. There was also reduction in body mass loss in treated groups. Thus it can be proposed that Sweitenia mahagoni leaf has potent anti-diabetic activity and the effect may be mediated through increasing the antioxidant strength, improving glycogen content in liver, balancing the lipid components in serum, decreasing the muscle protein catabolism and improved overall health
Article Information
28
3892-00
715
1199
English
Ijpsr
Naveen Y. P. and Asna Urooj *
DOS in Food Science and Nutrition, University of Mysore, Manasagangothri, Mysore, India
asnaurooj@foodsci.uni.mysore.ac.in
15 February, 2015
23 April, 2015
05 June, 2015
10.13040/IJPSR.0975-8232.6(9).3892-00
01 September, 2015
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