ANTI CONVULSANT POTENTIAL OF LEAVES OF PSIDIUM GUAJAVA LINN. IN MES AND PTZ INDUCED CONVULSION IN EXPERIMENTAL ANIMALS

Objectives: To study the anti-convulsant potential of leaves of Psidium guajava Linn. in MES and PTZ induced convulsion in experimental animals. Materials and methods: The anticonvulsant potential of the ethanolic extracts of Psidium guajava Linn. (EEPG) were tested in the mice model of Maximal electroshock (MES) and Pentylenetetrazole (PTZ). In the MES model, seizures were induced by delivering electroshock of 50 mA for 0.2 seconds via a pair of transauricular electrodes using an electro-convulsiometer. In the PTZ model, seizures were induced by injecting 80 mg/kg i.p Pentylenetetrazole (PTZ). For MES model, parameters measured were – duration of hind limb tonic extension, total recovery time and percentage protection. For the PTZ model, parameters measured were –duration of onset of clonic convulsions, duration of clonic convulsions, percentage reduction of clonic phase, mortality percentage and seizure score.  Results and Observation: The EEPG (200 mg/kg and 400 mg/kg) produced dose dependent anticonvulsant effect on MES induced seizures in albino mice, as suggested by reduction in the HLTE and total recovery time, and increase in the percentage protection from MES induced convulsions. EEPG also prolonged the latency of clonic convulsion and reduced the duration of convulsion in a dose dependent manner, as well as reduce the seizure score, thus suggesting the anticonvulsant effect of the extract on PTZ induced seizures. Conclusion: The present study concludes that the ethanolic extract of the leaves of Psidium guajava Linn. have anticonvulsant effect on PTZ and MES induced convulsion in albino mice.