STUDIES ON PHTHALIC ACID-PROPANE-1, 2-DIOL-GLYCEROL CO-POLYESTER AS AN ENTERIC COATING MATERIAL
AbstractEnteric coating material that, was synthesized in the laboratory and applied to a tablet and also drug release profile was investigated. A polymeric material – Phthalic acid propane-1,2 diol-glycerol co-polyester (PPGC) was synthesized from phthalic acid and propane-1, 2-diol with 5% glycerol of total weight as a crosslinking agent using Dean-Stark apparatus with Ferric Chloride as catalyst and o-xylene as the reaction medium. The polymer was dissolved in volatile organic solvent (Ethyl acetate) to prepare coating solution. The coating solution was sprayed over the DS tablet in a small coating pan with continuous hot air flow. The coating pan was allowed to rotate until the solvent evaporated and the tablet dried. The percentage of drug release from di-chlofenac sodium (DS) core and coated tablets (coated by phthalic acid-propane-1, 2-diol-glycerol co-polyester) instimulated gastric fluid (pH = 1.2) and in stimulated intestinal fluid (pH = 7.4), was investigated and according to B.P. standard drug release profile was obtained.
Article Information
28
4336-41
416
1259
English
Ijpsr
Md. Moinul Haque , Md. Saiful Islam *, Anath Chandra Roy and Md. Abu Bakr
Department of Applied Chemistry and Chemical Engineering, Rajshahi University, Rajshahi, Bangladesh
saiful@ru.ac.bd
04 April, 2015
27 June, 2015
15 September, 2015
10.13040/IJPSR.0975-8232.6(10).4336-41
01 October, 2015
Download