EVALUATING HYPOGLYCEMIC POTENTIAL OF KASNI (CICHORIUM INTYBUS) SEED PREPARATIONS IN TYPE 2 DIABETES MELLITUS PATIENTS

Objective: To evaluate hypoglycemic responses of Kasni (Cichorium intybus) seed preparations in combination with oral hypoglycemic agent in treatment of patients of newly diagnosed type2DM. Methods: Newly diagnosed 90 patients of type2DM, age 35-65years, of either sex were divided into 3 groups. Each group had 30 patients (19 male and 11 females) matched with each other in terms of age and sex. In group A, only Glycomet SR once a day  and in group B/C 6 grams crude seed powder or 50 ml decoction of crude seed powder twice a day in combination with Glycomet SR once in a day, was given for 90 days. FBG and PPBG were measured across 7 time periods and HbA1c levels were measured at zero and 90^th day. Results: All the three groups shown a significant reduction in FBG and PPBG across the seven time periods. Post hoc TukeyHSD test shown that there was a significant difference between group A&B (p=0.027) and group A&C (p=0.000) for FBG and group A&B (p=0.019) and group A&C (p=0.000) for PPBG. Significant decrease in HbA1c levels was also found. Post hoc TukeyHSD test shown that there was a significant difference between group A&B (p=0.032) and group A&C (p=0.003) for HbA1c. Conclusions: The adjuvant therapy with Kasni seed preparations in newly diagnosed type2DM patients in combination with oral hypoglycaemic agent is more effective than only oral hypoglycaemic agent in decreasing FBG, PPBG & HbA1c of selected patients and among Kasni seed preparations treated groups, decoction was found better than crude seed powder