ANTIHYPERGLYCEMIC ACTIVITY OF DIPTERACANTHUS PROSTRATUS NEES. AND ITS PROBABLE MECHNISM OF ACTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS

The present study was aimed to investigate the antihyperglycemic effect of the Dipteracanthus prostratus nees. And it’s probable mechanism of action in Streptozotocin induced diabetes. Wistar albino rats were used to evaluate the antihyperglycemic effect of toluene (TEDP, 100 mg/kg and 200 mg/kg, body weight) and methanolic (MEDP, 100 mg/kg and 200 mg/kg, body weight) extract of D. prostratus. Changes in body weight and blood glucose level were evaluated at the beginning of the experiment and on day 7, 14, and 21 subsequently. Lipid profile and histopathological examination were also performed. TEDP at 200 mg/kg produced a significant stimulating body weight and reduced blood glucose level in treated diabetic rats from day 7, apart that MEDP also showed similar activity from day 14.  Furthermore, significant differences in lipid profiles by TEDP treated rats at 200 mg/kg, as compared to diabetic control and normal rats were also observed. Histopathological studies showed comparable regeneration of islet cells necrosed by Streptozotocin, by both the extracts. In conclusion results revealed that the TEDP exhibited dose dependent significant and consistent hypoglycemic action. Probable mechanism of antihyperglycemic action of D. prostrates, in Streptozotocin induced diabetic rats were may be due to the presence of flavonoids and phenolic compounds in the extract.