SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL α-AMINOPHOSPHONATES BEARING A QUINOLINE MOIETY
AbstractA novel aminophenylaminoquinoline analogues have been synthesized starting from 4,7 dichloroquinloine and (p-phenylenediamine 2a, o-phenylenediamine 2b or m-phenylenediamine 2c). The one pot reaction with aldehydes and triphenylphosphite in presence of LiClO4 as a Lewis acid catalyst led to the formation of novel α-aminophosphonate derivatives bearing quinoline moiety in good yields. The synthesized compounds have been characterized on the basis of the spectral analysis. All the synthesized compounds were screened for in vitro antibacterial activity and most of them showed a potency against both gram positive and gram negative bacteria
Article Information
21
181-189
716
1904
English
IJPSR
Ahmed A. El Gokha, Ibrahim M. S. Ghanim, Ahmed El S. Abdel Megeed, Elkhabiry Shaban and Ibrahim El-Tantawy El Sayed*
Department of Chemistry, Faculty of Science, El Menoufia University, Shebin El Koom, Egyp
ibrahimtantawy@yahoo.co.uk
02 July, 2015
22 August, 2015
06 November, 2015
10.13040/IJPSR.0975-8232.7(1).181-89
01 January, 2016
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