SYNTHESIS, PHYSICO-CHEMICAL INVESTIGATIONS AND BIOLOGICAL SCREENING OF METAL (II) COMPLEXES WITH HYDRAZONE SCHIFF BASE DERIVED FROM 5-FLUORO-3-HYDRAZONOINDOLIN-2-ONE AND ISOPHTHALALDEHYDE
AbstractNew tetradentate Schiff base and its Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes formed by the condensation of 5-fluoro-3-hydrazonoindolin-2-one with isophthalaldehyde. The coloured complexes were prepared of [MLX2], Where L = Schiff base hydrazone, M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), X = Cl-. Physico-chemical characterization has been carried out to determine the structure of the complexes. All the synthesized compounds, were studied for their in vitro antibacterial, and antifungal activities, against two Gram-negative (Shigella flexneri and Enterococcus aerogens) and one Gram-positive (Micrococcus luteus,) bacterial strains and against three fungal strains (Candida krusiae Candida parasilopsis and Malassesia pachydermatis) by using cup-plate method. The DNA cleavage capacity of all the complexes was analysed by agarose gel electrophoresis method
Article Information
27
236-243
706
1655
English
IJPSR
K. Siddappa* and M. Nabiya Sultana
Department of Studies and Research in Chemistry, Gulbarga University, Gulbarga, Karnataka, India
siddappa_65@rediffmail.com
11 July, 2015
14 August, 2015
06 November, 2015
10.13040/IJPSR.0975-8232.7(1).236-43
01 January, 2016
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