COUMARINS: AN OVERVIEW OF MEDICINAL CHEMISTRY. POTENTIAL FOR NEW DRUG MOLECULES
AbstractFusion of a pyrone ring with a benzene nucleus gives rise to a class of heterocyclic compounds called Benzopyrones, of which two distinct types are recognized: (1) benzo-α-pyrone commomly called coumarins and (2) benzo-ϒ-pyrone called chromones or flavanoids, latter differing from former only in the position of the carbonyl group in heterocyclic system. Coumarins have attracted considerable attention of medicinal chemists and pharmacologists in recent years as they been demonstrated to bear various pharmacological activities like anti microbial, anti oxidant, anti inflammatory and analgesic, anti cancer, ulcerogenic, anti malarial, antihyperlipidemic, tyrosinase inhibitor, anti convulsant, anti-parkinsonian, antihepatitis, anticoagulant, cholinesterase inhibitor, vasorelaxant. This review focus on therapeutic importance of coumarins along with various methods of synthesis
Article Information
5
482-04
522
2952
English
IJPSR
Divya Singh*, Dharam Pal Pathak and Anjali
Department of Pharmaceutical Chemistry, Delhi Pharmaceutical Sciences Research University, Pushp Vihar, New Delhi, India
tsdivass7@gmail.com
08 June, 2015
24 August, 2015
06 January, 2016
10.13040/IJPSR.0975-8232.7(2).482-04
01 February, 2016
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