ANTI-DIABETIC PROFILE OF CINNAMON POWDER EXTRACT IN EXPERIMENTAL DIABETIC ANIMALS

Objective: to investigate the anti diabetic effect of ethanolic extract of Cinnamomum zeylanicum on Alloxan induced diabetes in experimental animals (Rats). Materials and Methods:  the alcohol extract of Cinnamomum zeylanicum was tested for its efficacy in Alloxan (150mg/kg) induced diabetic rats. The diabetic rats were divided into 5groups. Group I (control) received 2% gumacasia, groupie (positive control) received standard drug Glibenclamide (10mg/kg+2%GA), group III, IV, V (T₁ T₂ T₃) were treated orally with a daily dose of 50mg/kg, 100mg, 200mg, respectively for 30 days, for all diabetic rats after giving Test, NC, PC preparations, the blood samples were collected and determined the blood glucose level 0,1,3,24hrs intervals. 0hr reading is before drug giving and remaining 3 readings after drugs giving. 24^th her reading is considered as 0hr reading for the next day. Results: administration of alcohol of an extract of Cinnamomum zeylanicum produced a dose dependent decrease in blood glucose levels in Alloxan induced rats. There was significant fall in blood sugar level in High dose (200mg/kg) in comparison to low dose (50mg/kg) and median dose (100mg/kg) shown by LSD test. This is comparable to the effect of Glibenclamide. Conclusion: the results of this study show that chronic oral administration of an extract of Cinnamomum zeylanicum at an appropriate dosage may be good alternative anti diabetic agent