FORMULATION, OPTIMIZATION & EVALUATION OF TRANSDERMAL PATCHES OF SALBUTAMOL SULPHATE
AbstractAim: The objective of the present research work was to formulate and compare two different kinds of penetration enhancer in transdermal patch with placebo patch using a drug (Salbutamol sulphate) and compare for in vitro drug release. Study Design: The transdermal patches of Salbutamol sulphate were prepared by solvent evaporation technique using different ratios of Hydroxy propyl methylcellulose (HPMC K15M) and Poly vinyl propylene (PVP K30). The prepared transdermal patches were evaluated on parameters like weight variation, thickness uniformity, moisture content, moisture uptake, folding endurance, tensile strength, drug content, in vitro dissolution studies, in vitro drug release, skin irritation test and stability studies. Maximum drug release was showed by Batch T, and the optimized formulation showed satisfactory characteristics
Article Information
24
1572-79
711
1923
English
IJPSR
Rakesh Kumar*, Nidhi Saini and Kamal Saroha
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India
rakeshkumar2750@gmail.com
20 October, 2015
14 January, 2016
18 March, 2016
10.13040/IJPSR.0975-8232.7(4).1572-79
01 April, 2016
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