A STUDY ON THE EFFECT OF VIRGIN COCONUT OIL ON BENZO(A)PYRENE INDUCED GASTRIC NEOPLASIA IN MICE.
AbstractObjective: The present investigation is focused on detecting anti-carcinogenic potential of virgin coconut oil. Methods: The virgin coconut oil (VCO) from coconut endosperm was prepared by cold compression method. It was examined then for cytotoxicity by cell exclusion studies using trypan blue dye. Chemical carcinogenesis method using benzopyrene was used to study the anticarcinogenecity of VCO. Curcumin was taken as standard. The low dose and high dose VCO was compared with normal, vehicle and standard treatments. Biomarker studies and histopathological evaluation was also performed. Result: The VCO upto 9μl showed no significant cytotoxicity. The low dose (4ml/kg body wt) and high dose (8ml/kg body wt) of VCO had significant reduction in gastric Lactate Dehydrogenase (LDH) activity, which is a biomarker for gastric cancer. Histopathological reports also showed very less infiltrations and absence of hyperplasia compared to control. Conclusion: The present study showed that, the virgin coconut oil have anti-carcinogenicity property, thus it prevent hyperplasia in the stomach of mice, induced by benzopyrene
Article Information
15
1948-55
532
1326
English
IJPSR
Anu Alex *, N. K. Nair , Shawn Tomy , K.Elango and C. R. Achuthan
Department of Pharmacology, JSS College of Pharmacy, Ooty (JSS University, Mysore), Tamil Nadu, India
koshy_alex_punthala777@hotmail.com
18 November, 2015
15 February, 2016
18 March, 2016
10.13040/IJPSR.0975-8232.7(5).1948-55
01 May 2016
Download