SIMULTANEOUS ESTIMATION OF ALFUZOSIN AND DUTASTERIDE IN TABLET DOSAGE FORM BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
AbstractA simple, accurate, economic and rapid method for the simultaneous estimation of Alfuzosin and Dutasteride by RP-HPLC, as a result simple, economic, precise and accurate methods was developed and validated by Reverse Phase High performance Liquid Chromatography in tablet dosage form. The mobile phase consisted of Acetonitrile and Buffer solution in the ratio of (75:25) was eluted through universil C18 column (150 mm x 4.6 mm, i.d., 5µm particle) at a flow rate of 1.0 ml/min. The column temperature was 25ºC. The eluent was monitored at 225 nm for detection of Alfuzosin and Dutasteride by the UV detector. The detection time was 8 min. The validation of HPLC method was carried out in accordance with the ICH guidelines.
Article Information
17
2896-04
605
1408
English
IJPSR
K. Sonia* and M Nappinnai
Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM University, Kattankulathur, Tamil Nadu, India.
soniapharm68@yahoo.com
22 February, 2016
09 April, 2016
16 April, 2016
10.13040/IJPSR.0975-8232.7(7).2896-04
01 July 2016
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