ANTICONVULSANT ACTIVITY OF THE METHANOLIC EXTRACT OF LAWSONIA INERMIS LEAVES IN ALBINO RATS
AbstractThe aim of the study was to determine the anticonvulsant activity of methanolic extract of Lawsonia inermis leaves in albino rats. The anticonvulsant activity of methanolic extract of leaves of Lawsonia inermis (200 mg/kg and 400 mg/kg) was assessed in rats using maximum electroshock seizure (MES) test and pentylenetetrazole (PTZ) induced seizure test. The methanolic extract of Lawsonia inermis leaves significantly (p<0.01) reduced the hind limb tonic extension in the MES test in a dose dependent manner. In the PTZ model also, the extract signicantly (p<0.01) reduced the duration of clonic convulsions as well as delay the onset of seizures in a dose dependent manner. The study demonstrates that Lawsonia inermis has significant anticonvulsant activity possibly through a GABA-ergic interaction
Article Information
39
3068-72
296
1484
English
IJPSR
A. Saikia*, A. Purkayastha, R. Tigga and D. Roy
Department of Pharmacology, Silchar Medical College and Hospital, Silchar, Assam, India
avinashsaikia24@gmail.com
21 February, 2016
05 April, 2016
04 May, 2016
10.13040/IJPSR.0975-8232.7(7).3068-72
01 July 2016
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