FORMULATION AND CHARACTERIZATION OF DILTIAZEM HYDROCHLORIDE MATRIX TABLETS BY USING NATURAL POLYMERS
AbstractThe purpose of present study was to design and evaluate matrix tablets of Matrix tablets of Diltiazem hydrochloride were prepared by using natural polymers like Gum karaya and Gum kondagogu. The pre formulation study was performed on combination of drug with polymers by FTIR suggested that drug and polymers were compatable. The matrix tablets were prepared by using by wet granulation method. All the prepared tablets were evaluated for weight variation, hardness, friability, drug content uniformity and in vitro drug release characteristics. The formulation F4 shows the 99.75% of drug release up to 12 h when compared with all other formulations. Formulation containing diltiazem hydrochloride with gum karaya shows best and maximum drug release of 99.75% up to 12hrs
Article Information
25
3764-69
503
1250
English
IJPSR
P. Dwarakanadha Reddy *, D. Vijaya Bharathi, D. Swarnalatha and C. Gopinath
Annamacharya College of Pharmacy, Rajampeta, Kadapa, Andhrapradesh, India
dwarakanadha.reddy25@gmail.com
25 April, 2016
28 May, 2016
06 July, 2016
10.13040/IJPSR.0975-8232.7(9).3764-69
01 September 2016
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