DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF CELIPROLOL HYDROCHLORIDE IN TABLET FORMULATION
AbstractSimple, specific, accurate and cost economic UV spectrophotometric methods were developed and validated for determination of Celiprolol Hydrochloride. Instead of using organic solvents, mixture of dilute hydrochloric acid and water was used during method development and validation. The drug was extracted from tablet formulation with a mixture of water and hydrochloric acid. Stability of drug solution and formulation was established throughout the analysis time. Zero Order Derivative and Area Under Curve methods were developed for estimation of drug and both the methods were validated as per ICH guidelines. The linearity of drug was established by performing calibration curve. The analytical range of drug was established from linearity study. Precision of the method was established with Intraday and interday analysis. Accuracy was established by conducting recovery study. Robustness of both the methods was confirmed by conducting analysis with different analysts
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