EVALUATION OF ANTIASTHMATIC ACTIVITY OF CITRULLUS COLOCYNTHIS FRUIT
AbstractThe present investigation was under taken to evaluate the anti-asthmatic activity of ethanolic extract of Citrullus colocynthis Fruits in experimental animals. Citrullus colocynthis Fruits was evaluated for anti-histaminic activity using isolated goat tracheal chain preparation and histamine induced Bronchoconstriction in Guinea pig. Citrullus colocynthis Fruits significantly inhibited dose dependent contraction of goat tracheal chain produced by histamine and also showed significant protection by prolonging Preconvulsion dyspnea time (PCD) in guinea pigs. Thus, Citrullus colocynthis Fruits showed anti-allergic activity against histamine and hence possesses potential role in the treatment of asthma.
Article Information
27
716-721
484
1381
English
Ijpsr
Chandan Genwa *, Umesh K. Gilhotra, Anil K. Varma and Bhawna Rajpurohit
G. D. Memorial College of Pharmacy, Jodhpur, Rajasthan, India.
chandangenwa7574@gmail.com
08 August, 2016
13 September, 2016
17 November, 2016
10.13040/IJPSR.0975-8232.8(2).716-21
01 February, 2017
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