SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF 3-SUBSTITUTED SCHIFF BASES OF QUINAZOLINE2,4-DIONES

Objective: 3-Substituted Schiff bases of Quinazolne-2,4-diones belongs to the N-containing heterocyclic compounds. The aim of the present study is to synthesis and characterization of ten novel derivatives of 3-Substituted Schiff bases of Quinazoline2,4-diones and their pharmacological study. In the current course of work the novel Schiff bases of Quinazolne-2,4-diones  which are synthesized  are evaluated for Anti-bacterial study.  Materials and Methods: Present research synthesis work of 3-Substituted Schiff bases of Quinazoline 2,4-diones involve two step along with greener method and conventional method of synthesis. 3-Substituted Schiff bases of Quinazoline 2,4-diones have been evaluated for Anti-bacterial study by disc diffusion method. Result: The Schiff bases of quinazoline2,4-diones have been synthesized successfully as per the designed scheme of synthesis which includes Greener and conventional method. The greener method found to the more advantageous as compared to the conventional method. These compounds are characterized by various physicochemical and spectral analysis by the FT-IR spectral analysis and 1H-NMR.  The Synthesized compounds possessed the antibacterial activity. Conclusion: The result of the present research study thus demonstrates the Anti-bacterial activity of newly synthesized 3-Substituted Schiff bases of Quinazolne-2,4-diones.