SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SUBSTITUTED N-(3-FORMYL-4-OXO-4H-CHROMEN-2-YL)-N- PHENYLBENZENESULFONAMIDE AND ITS DERIVATIVES

Modification of a drug molecule of a series having optimal activity is widely used and continues to be an important factor necessary for new drug discovery. Infectious diseases which increase dramatically by resistant and multi resistant microbes are now a days the second major cause of death worldwide and the third leading cause of death in the developed countries. Although, the search for new lead structures for the development of antimicrobial agent is an increasingly important problem in medicinal chemistry. The treatment of infectious diseases still remains an important and challenging area of research due to multidrug resistance by microbes. The increasing incident of drug resistance in treatment of microbial diseases emphasizes worldwide need for newer antimicrobial agents. To treat these infectious diseases, a route is established to synthesize the pharmacological active novel chromone based sulfonamide derivatives i.e. substituted N- (3 –formyl -4-oxo -4H –chromen -2-yl) -N-phenyl benzene sulfonamide having antibacterial and antifungal activities. The objectives of the present work are: 1) To synthesize various derivatives of substituted N-(3-formyl-4-oxo-4H-chromen-2-yl)-N-phenyl benzene sulfonamides. 2) To analyses all synthesized derivatives by their respective spectral data. 3) To evaluate the antibacterial and antifungal activities.