PROTECTIVE EFFECTS OF FERULIC ACID AGAINST LIVER CHOLESTASIS INDUCED BY ETHINYLESTRADIOL IN ADULT FEMALE RATS
AbstractThe aim of the present article was to examine the protective effect of ferulic acid against liver cholestasis in female rats treated with ethinylestradiol (EE). The daily oral administration of the ferulic acid at a concentration of 40 mg/kg body weight for 15 days to rats treated with EE (100 µg/kg body weight for 5 days) resulted in a significant protection against EE-induced decrease in plasma cholesterol, bile acid, hepatic reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (Gpx), and catalase (CAT) levels as well as against an increase of plasma bilirubin, alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), malondialdehyde (MDA), 5′- Nucleotidase, interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α). The results clearly suggest that ferulic acid has a powerful prophylactic action in cholestasis induced by EE.
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