TERBINAFINE INCORPORATED SODIUM HYALURONATE MICROSPHERE MUCO-ADHESIVE SYSTEM FOR VAGINAL CANDIDIASIS
AbstractThe aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal microspheres containing Terbinafine (TBH) in order to provide long-term therapeutic activity at the site of infection and prove the same using in vitro anti fungal activity of the same using Candida albicans. Microspheres were prepared by the Solvent extraction technique using sodium hyaluronate and Arlacel A. Microspheres were characterized by SEM, DSC, FTIR, particle size analysis and evaluated for percentage yield, drug loading, encapsulation efficiency and in vitro drug release. FTIR and DSC studies showed that no chemical changes or alterations occurred in the drug and polymers. The sphericity factor indicated that the prepared microspheres were spherical. Formulation (TBHMs) indicated a controlled in vitro drug release and good bioadhesive strength. The in vitro anti fungal activity confirmed for a controlled and prolonged capacity of the prepared novel formulation. The results indicated that this drug delivery system can be explored for controlled intra-vaginal drug release.
Article Information
32
4767-4776
607
1165
English
IJPSR
S. Venkatachalam, M. V. Harsha*, M. Pooja and M. Paranjothy
Department of Pharmaceutics, JSS College of Pharmacy, Rockland's, Jagadguru Sri Shivarathreeswara University, Mysuru, Udhagamandalam, Tamil Nadu, India.
Harshavenkatesh.adapa@gmail.com
28 March, 2017
11 May, 2017
27 May, 2017
10.13040/IJPSR.0975-8232.8(11).4767-76
01 November, 2017
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