ANALGESIC, ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITY OF TRICHOSANTHES DIOICA ROXB. LEAF EXTRACTS

Aim of the study: This study evaluates the analgesic, anti-inflammatory and antipyretic activities of the aqueous, methanol and n-hexane extracts of Trichosanthes dioica Roxb. to provide experimental evidence for its traditional use such as fever, pain and inflammation. Materials and methods: Investigations on the analgesic effects of Trichosanthes dioica Roxb. was carried out by acetic acid-induced writhing using Aspirin as standard. The anti-inflammatory activity was observed by carrageenin-induced edema of the hind paw of rats using indomethacin as standard. The antipyretic activity was observed by yeast induced pyrexia in rat using Paracetamol as standard. Results: It has been shown that the methanol and aqueous extracts significantly reduced acetic acid-induced writhing response in mice. The methanol and aqueous extracts remarkably inhibited the increase in vascular permeability induced by acetic acid and also significantly decreased the carrageenin-induced rat paw edema perimeter. The methanol and aqueous extracts also shows reduction of body temperature in yeast induced pyrexia in rat model. Conclusion: The results show that the methanol and aqueous extracts have analgesic activity and as anti-inflammatory effects, supporting the traditional application of this herb in treating various diseases associated with inflammation and pain. The result also shows that the methanol and aqueous extracts have moderate antipyretic activity. Out of methanol and water extract, methanol extract shows better analgesic, anti-inflammatory and antipyretic activity with respect to the standard used.