ANTIASTHMATIC EFFECT OF LEAVES OF EVOLVULUS ALSINOIDES

Evolvulus aslsinoides is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antioxidant and antiasthmatic activity of ethanol extract of Evolvulus aslsinoides leaves. The present investigation was undertaken to evaluate the histamine-induced bronchospasm of alcoholic extract of Evolvulus aslsinoides leaves in experimental animals. Bronchodilator activity of aqueous extract of Evolvulus aslsinoides leaves studied on the histamine aerosol induced bronchospasm in wister rats.  Treatment with alcoholic extract of Evolvulus aslsinoides leaves (250 mg/kg, p.o) showed significant protection against histamine aerosol induced bronchospasm in wister rats. The results of the histamine-induced bronchospasm paradigms demonstrate bronchospasmolytic activity of ethanolic extract of Evolvulus aslsinoides leaves (250 mg/kg, p.o.). Evolvulus aslsinoides leaves shows 41.49% protection against histamine induced bronchoconstriction in rats. These results suggest that aqueous extract of Evolvulus aslsinoides leaves has not only bronchodilating activity but also decreases bronchial hyperreactivity by decreasing the infiltration of inflammatory cells in the airway and inhibition of release of histamine like mediators from the mast cell by stabilizing it. Evolvulus aslsinoides is useful in asthma, emmanagogue, lever trouble, chronic broncihitis, opthalmia, toothache, and stomatitis.