ANTIOXIDANT ANALYSIS AND ENZYME INHIBITION ASSAY OF PLANTS OF APOCYNACEAE FAMILY FOR ULCERS

Different plants of the Apocynaceae family viz. Alstonia scholaris, Calotropis procera, Rauvolfia serpentine, Hemidesmus indicus and Calotropis gigantean are traditionally being reported in ulcers treatments. The present study was aimed to validate the authenticity of correlationship of various phytoconstituents concentrations, antioxidant activity and urease inhibitory potential of the same. Various methods of antioxidant potential possess variable modes of deactivation of free radicals. Plants possess myriad of chemical entities, an effort has been made to assign antioxidant and urease inhibitory putativity to various classes of compounds. The Flavonoid content seemed significant for antioxidant as well urease inhibitory potential. Calotropis procera and Calotropis gigantean possessed 104.11mgRU/g and 97.34mgRU/g of flavonoids. The two exhibited 39% and 40% urease inhibitory potential respectively. The ferric reducing power and the β- carotene bleaching tendency were highest in both species of Calotropis genus. Pearson’s correlation coefficient between total flavonoids-urease inhibitory percentage, β-carotene bleaching – flavonoids and FRAP – flavonoids content was significant. So the plants of Calotropis genus have good potential for the management of ulcers, gastric disease and related conditions of oxidative stress.