FAST DISSOLVING TABLETS OF FEXOFENADINE HYDROCHLORIDE BY MELT TECHNOLOGY: FORMULATION AND CHARACTERIZATION
AbstractThe objective of present study was formulation and evaluation of fast release tablets of Fexofenadine hydrochloride. Fexofenadine hydrochloride is an anti-histamine with selective H1-receptor antagonist activity. In this investigation fast release tablets of Fexofenadine hydrochloride were prepared using cross povidone as a superdisintegrants by melt technology method. The Fourier transform infrared spectroscopy revealed absence of any drug – excipient interactions. The tablets were evaluated for pre-compressed evaluation like bulk density, tapped density, Hauser’s ratio, Carr’s index and angle of repose and post-compressed evaluation like weight variation, thickness, hardness, friability, wetting time, disintegration time, content uniformity and in-vitro drug release profile. The wetting time for all batches was found in the range of 20.1 to 80.1 sec. All the tablets were disintegrated within 100 seconds. In-vitro percent drug release was found up to 98.25 % in 30 min. The formulation 4 showed better result in wetting time, disintegration time and drug release profile.
Article Information
46
1226-1230
410
1423
English
IJPSR
B. Gupta* and S. Kumar
NKBR College of Pharmacy and Research Centre, Hapur Road Phaphunda, Meerut, Uttar Pradesh, India.
gupta.bhavana35@gmail.com
04 June, 2017
28 November, 2017
06 January, 2018
10.13040/IJPSR.0975-8232.9(3).1226-30
01 March, 2018
Download