ADULTERATION AND SUBSTITUTION IN ENDANGERED, ASU HERBAL MEDICINAL PLANTS OF INDIA, THEIR LEGAL STATUS, SCIENTIFIC SCREENING OF ACTIVE PHYTOCHEMICAL CONSTITUENTS

Endangered Indian medicinal plants have used as traditional and alternative Indian system of medicine (ISM) from last several ancient time. In 20^th and 21^th – century generation are becoming aware of the side effect and adverse reaction of synthetic drugs and so there is an increasing interest, Scope of innovating in herbal medicinal plants based Ayurvedic, Siddha, Unani (ASU) medicinal products. In the continuously using of Adulteration and Substitution, Spurious drugs on the place of original Indian endangered and costly ASU. Herbal medicinal plants hence today generate the major task of Indian drug regularity affaire, drug controlling approach, as well as herbal industries, face the burning problem. Resulted growing high altitude region many endangered and rare, costly original medicinal species such as these are Vatsnabh, (Aconitum Chasmanthumstapfex. Haimes), Ativishaor Atis, (Aconitumheterophylum Wall. Ex. Royal), Kutki, (Picrorhiza kurroa royleex), Kuth or Kustha, (Saussurea lappa C.B.CL.), Puskarmool, (Inularacemosa Hook.F.), Riddhi, (Hobenariainte media D. Don), Vriddhi, (Habenariaedge worthii Hook.f.ex.Collett), Kakoli, (Roseea purpurrea Smith), Kshirakakoli, (Fritillariar oylei Hook) and (Lilium polyphyllum D. Don), Jeevak, (Crepipiuma cumina tum D. Don.) Szlach.), Meda, (Polygonatum verticillatum Linn.) Allioni), Mahameda, (Polygonatum cirrhifolium (wall.) Royal) and (Polygonatum Vertecillatum Alloi), Rakta Chandana, Sandal Surkh, (Pterocarpus santalinus Linn.), Sveta Chandana, Sandal Safed, (Santalum album Linn.), Kesar, Keshar or Kum Kum, Zafran ,(Crocus sativus Linn.), etc. completely endangered and incorrect identification of their intestinally or unintentionally, Finally they become effectively adulterated and substituted in condition. The present communication investigates research review has reported their drug regularity affaire and drug controlling, pharmacovigilance approach of Adulteration and Substitution, Spurious drugs with active phytochemical constituents, extensive taxonomical and ethnobotanical authentication, medicinal properties of these several endangered and costly medicinal plants.