SYNTHESIS AND CHARACTERIZATION OF POTENTIAL IMPURITIES OF ARIPIPRAZOLE
AbstractAripiprazole is an anti-psychotic drug used in the treatment of psychosis, including schizophrenia, and during process development for Aripiprazole, we observed two related substances. This paper describes the preparation, identification and proposed structures of the impurities 7-(4-(4-(2-chlorophenyl) piperazine-1-yl) butoxy) – 3, 4 – dihydroquinoline – 2(1H) – one and 7- (4-(4-(3-chlorophenyl)piperazin-1-yl) butoxy)-3,4-dihydroquinoline-2(1H)-one formed during reaction of 7-(4-bromobutoxy)-3, 4-dihydroquinoline-2(1H)-one with 1-(2, 3-dichloro phenyl) Piperazine Hydrochloride to form Aripiprazole.
Article Information
67
4046-4050
569
3893
English
IJPSR
J. Verdia *, P. Kumar and N. S. Joshi
Research and Development Centre, Amoli Organics Pvt. Ltd., Village Luna, Padra, Vadodara, Gujarat, India.
jitendra.verdia@amoliindia.com
05 March 2014
26 June 2014
18 June 2014
10.13040/IJPSR.0975-8232.5(9).4046-50
01 September 2014
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