EFFECT OF POLYMER IN RELEASE PROFILE OF EXTENDED RELEASE MATRIX TABLET OF ANTI-HYPERTENSIVE DRUG & TO STUDY IMPACT OF AGGLOMERATIVE PHASE OF COMMINUTION (APOC) METHOD ON DRUG RELEASE

The objective of this study is to develop extended release matrix tablet of antihypertensive drug benidipine hydrochloride (BH) and to study its drug release pattern. BH has mean elimination half-life is ~3 h and requires dosing every 4 – 5 h in order to maintain optimal relief and is used orally in the management of hypertension and angina pectoris, but this frequent administration produces side effects like dizziness, headache. So in this study we have achieved to release drug for extended period of time up to more than 18 h for treatment of hypertension, for continuous 24 h control of blood pressure (BP), by taking polymers hydrophilic polymers, hypromellose (hydroxyl propyl methyl cellulose [HPMC] K100M), and polyacrylate polymers, eudragit RL100 and eudragit RS100 and also chitosan (CS) in order to find the suitable formulation. The tablets were prepared by direct compression method and also agglomerative phase of comminution (APOC). In-vitro drug release was carried out under simulated gastric and intestinal condition to achieve drug release. Fourier transform infrared spectroscopy (FTIR) study was performed to study any interaction. Stability studies (40 ºC and 75 ± 5% RH) for 3 months indicated that benidipine hydrochloride (BH) was stable in the matrix tablets.