SYNTHESIS AND IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF SUBSTITUTED-2, 3-DIMETHYL-N-(3-(4-PHENYL PIPERAZIN-1-YL) PROPYL)-6, 7-DIHYDRO-5H-BENZO [7] ANNULENE-8-CARBOXYLIC ACIDS

Benzosuberones and phenylpiperazinyl moieties are important heterocyclic compounds which constitute many biological activities which include anti bacterial, anti fungal, anti inflammatory, antioxidant, antitubercular and anti cancer activities. A novel series of 2,3-dimethyl-N-(3-(4-phenyl piperazin-1-yl)propyl)-6,7-dihydro-5H-benzo[7] annulene-8-carboxylic acids (5a-e) have been synthesized in good to excellent yields by experimental simplicity and milder reaction conditions and evaluated for their anti-proliferative activity. The titled compounds were identified and characterized by IR, ¹H NMR, ¹³C NMR and mass spectral analysis. The novel derivatives synthesized were evaluated for in-vitro anti-proliferative activities on four different human cancer cell lines He La (cervical), MIAPACA (pancreatic), MDA-MB-231 (breast) and IMR32 (neuroblastoma) by sulphorhodamine B assay method. These synthesized novel derivatives which showed excellent anti-proliferative activity. The obtained results suggest that these classes of compounds can be considered as new hits for further structural optimization to obtain better anti-proliferative drug development program.